Dr Steven J Coles

dr-steven-j-coles

Senior Lecturer in Biochemistry

Biological Sciences

Contact Details

email: s.coles@worc.ac.uk
tel: 01905 542577

Office: EEG081

Steve joined us in February 2013 and is our award leader for the BSc Biochemistry programme. Since joining us, Steve has introduced several new modules to the bioscience degree programmes which are informed by his research and expertise, including: BIOS2110 Immunology and BIOS3113 Biochemistry of Cancer. Steve is committed to teaching and learning and has achieved several student led teaching awards in recognition of his efforts including the Deputy Vice Chancellors Award for Excellence in Teaching.

Steve achieved a first class honours degree in Biochemistry and Molecular Biology at the University of the West of England (UWE, 2005) before undertaking a PhD in Biomedical Sciences (Neurochemistry) which he attained in 2008 (UWE). Following his studies, Steve joined the School of Medicine at Cardiff University as a post-doctoral research scientist (Department of Haematology), where his research focussed on tumour immunology and immunotherapy in a type of blood cancer known as acute myeloid leukaemia (AML).

Steve's research interests include, cancer immunology, exercise immunology, diagnostics and the role of oxidative stress in disease pathogenesis. Since joining us, Steve has established an independent research profile and is the Worcester Biomedical Research Group (WBRG) lead.

Undergraduate teaching

Module Leader

First Year
BIOS1205 Introduction to Biological Chemistry (15 credit)
BIOS1212 Introduction to Biological Chemistry & Genetics (30 credit)

Second Year
BIOS2110 Immunology (15 credit)

Third Year
BIOS3113 Biochemistry of Cancer (15 credit)
BIOS3116 Clinical Chemistry (15 credit)

Steve also contributes to teaching on several other modules including: BIOS1201 Cell Biology, BIOS1211 Introduction to Human Health & Disease, BIOS2200 Project & Career Development, BIOS2201 Molecular & Cellular Biology (semester 2) and BIOS2023 Microbiology.

Research

Steve currently leads several Biomedical research projects at the University of Worcester:

PhD Students
Mr James Hillier (BSc, MSc) - The Role of BCAT1 in the Development and Treatment of AML (as Director of Studies) 2015 2018.

Sr Angela Doughty(BSc) - Monitoring Intracellular and Extracellular Markers of Oxidative Stress in Acute Coronary Syndrome (as Director of Studies) 2015 2020 part-time.

Recently Completed Projects

Post-doctoral Dr Alex Wadley (PhD) - Validating a Novel Flow Cytometric Assay to Assess the Functional Consequence of Intracellular Thiol-Redox Status in Viable Peripheral Blood Mononuclear Cells: implications for AML anti-tumour immunity­ (as Principle Investigator) 2014 2017.

PhD Project Ideas

Funding and Awards

2018 -
£48,233 (Sir Halley Stewart Trust) Development of a rapid and cost-effective Point-of-Care diagnostic test for the detection of Ureaplasma infection among preterm neonates as Co-Investigator with Dr Michael Beeton (Cardiff Metropolitan University).
2018 - £4,450 (Institute of Biomedical Science) Development of a rapid diagnostic test for the stratification of BCAT1 overexpressing acute myeloid leukaemia as Principle Investigator.
2015 - £28,900 (CAPES: Ministry of Education, Brazil) The role of GLUT12 transporters in disease pathogenesis as Co-Investigator with Dr Allain Bueno (Principle Investigator)
2015 - £9,756 (Sir Halley Stewart Trust) High throughput in vitro screening of novel therapeutics for the treatment of parasitic infection and leukaemia (AML) as Co-Investigator with Dr Wayne Heaselgrave (University of Wolverhampton)
2015 - £44,589 (University of Worcester) PhD Studentship The role of BCAT1 in the development and treatment of AML
2014 - £91,328 (University of Worcester) Post-Doctoral Research Associate Validating a Novel Flow Cytometric Assay to Assess the Functional Consequence of Intracellular Thiol-Redox Status in Viable Peripheral Blood Mononuclear Cells: implications for AML anti-tumour immunity
2014 - £1,000 (University of Worcester) Summer Studentship cloning BCAT1 into a lentiviral vector
2013 - £1,000 (University of Worcester) Summer Studentship Detecting intracellular protein targets of oxidative stress
2013 - £1,000 (University of Worcester) Summer Studentship Plasma markers of oxidative stress
2012 - £300 (BioLegend) Young investigator award
2011 - £200 (William Morgan Trust) Travel award to BSI congress
2011 - £500 (British Society for Immunology) Travel award to BSI congress
2010 - £500 (American Society for Hematology) Travel award to ASH annual meeting
2010 - £1,000 (British Society of Haematology) Travel award to ASH annual meeting

Collaborators

Dr Wayne Heaselgrave (PhD) - University of Wolverhampton
Dr Michael Beeton (PhD) - Cardiff Metropolitan University
Prof Myra Conway (PhD) - University of the West of England
Prof Richard Darley (PhD) - Cardiff University
Dr Paul Hole (PhD) - Cardiff University
Dr Rhys Morgan (PhD) - University of Sussex
Dr Alex Wadley (PhD) - Loughborough University

Publications

Selected Journal Articles

Wadley, A.J., Holliday, A., Morgan, R.G., Heesom, K.J., Aldred, S., Peters, D.M., Bueno, A.A. and Coles, S.J. (2018) Preliminary evidence of reductive stress in human cytotoxic T cells following exercise. J. Appl. Physiol DOI: 10.1152/japplphysiol.01137.2017. https://www.ncbi.nlm.nih.gov/pubmed/29648517

Wadley, A.J., Aldred, S. and Coles, S.J. (2016) An unexplored role for peroxiredoxin in exercise-induced redox signalling? Redox Biol DOI: doi: 10.1016/j.redox.2015.10.00. https://www.ncbi.nlm.nih.gov/pubmed/26748042

Coles, S.J., Gilmour, M., Reid, R., Knapper, S., Man, S., Tonks, A. and Darley R.L. (2015) The immunosuppressive ligands PD-L1 and CD200 are linked in AML immunosuppression: identification of a new immunotherapeutic synapse. Leukemia DOI: 10.1038/leu.2015.62.
http://www.ncbi.nlm.nih.gov/pubmed/25748687

Agathanggelou, A., Weston, V.J., Perry, T., Davies, N.J., Skowronska, A., Payne, D.T., Fossey, J.S., Oldreive, C.E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, S.J., Hole, P.S., Darley, R.L., McMahon, M., Hayes, J.D., Moss, P., Stewart, G., Taylor, M.R. and Stankovic, T. (2015) Targeting the ATM-null phenotype in chronic lymphocytic leukemia with pro-oxidants. Haematologica DOI: 10.3324/haematol.2014.115170.
http://www.ncbi.nlm.nih.gov/pubmed/25840602

For a complete list of Steves publication, please follow the link to his ORCID page: http://orcid.org/0000-0002-1109-6971

Conference Papers and Published Abstracts$

Coles, S.J., Gilmour, M., Reid, R., Knapper, S., Man, S., Tonks, A. and Darley R.L. (2014) CD200 and PD-L1 in AML are associated with expanded late differentiated CD8+ T cells and a decreased CD4:CD8 ration; a new link between distinct immunosuppressive pathways. Blood (ASH Annual Meeting Abstracts) 124, 992. Poster$ (clinically relevant)
http://www.bloodjournal.org/content/124/21/992?sso-checked=true

Coles, S.J., Hills, R.K., Wang, E., Man, S., Burnett, A.K., Darley, R.L. and Tonks, A. (2011). CD200 inhibits memory Th1 cell function in acute myeloid leukaemia. Immunology (BSI Annual Meeting Abstracts) 135, 178. Poster$
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2011.03534.x/abstract

Coles, S.J., Man, S., Hills, R.K., Wang, E., Burnett, A.K., Darley, R.L. and Tonks, A. (2010). Over-expression of CD200 in Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity. Blood (ASH Annual Meeting Abstracts) 116, 491. Oral$ (clinically relevant)
http://abstracts.hematologylibrary.org/cgi/content/abstract/116/21/491

Coles, S.J., Man, S., Wang, E., Burnett, A.K., Darley, R.L. and Tonks, A. (2010). RUNX1-ETO target genes; the role of CD200 mediated tumour immunity in AML. 17th RUNX transcription factors in development and disease, Hiroshima Japan July 2010. Oral

Coles, S.J., Wang, E., Mans, S., Burnett, A.K., Darley, R.L. and Tonks, A. (2010). The immunosuppressive protein, CD200, promotes natural killer dysfunction in acute myeloid leukaemia. Wales Cancer Conference, April 2010. Oral

Coles, S.J., Man, S., Wang, E., Burnett, A.K., Darley, R.L. and Tonks, A. (2009). The role of CD200 in AML tumour immunity. 16th RUNX transcription factors in development and disease, Oxford UK August 2009. Poster

Coles, S.J. Hancock, J., Hutson, S. and Conway, M.E. (2007). S-nitrosylation of the human branched chain aminotransferase isoenzymes. UK 8th NO forum, Bradford, UK, Dec 2007. Oral

Coles, S.J., Hutson, S.M., Hancock, J. and Conway, M.E. (2006). S-nitrosylation, redox regulation and the human branched chain aminotransferase (hBCATc). Biochemical Society, Glasgow, UK, June 2006. Poster

Conway, M.E. Coles, S.J. Islam, M, Mallet, C. and Hutson, S.M. (2006). The human branched chain aminotransferase (hBCATc) differs in sensitivity to peroxide compared to the mitochondrial isofrom. Biochemical Society, Glasgow, UK, June 2006. Poster

Book Chapters

Chapter 10 in Redox Mediated Signal Transduction (2008). Springer (ISBN 978-1-58829-842-3), 136-152.

Professional bodies and committees

Chair of the ISE Health and Safety Committee 
Worcester Biomedical Research Group Lead 
Member of the Genetically Modified Organisms Committee 
Member of the Worcester Health Research Committee

Fellow of the Institute of Biomedical Sciences
Member of the British Society for Immunology

 

External Roles

Editor for Cancer and Oncology: Open Access Journal