Dr Allain Bueno

Dr Allain Bueno

Principal Lecturer in Human Biology and Human Nutrition

Biological Sciences

Contact Details

email: a.bueno@worc.ac.uk

Dr Bueno joined the University of Worcester in January 2012, after 4 years of Post-doctoral experience at the Institute of Brain Chemistry and Human Nutrition in London, working with Prof Michael Angus Crawford, one of the pioneers in fatty acid metabolism and brain composition.

Whilst in London, Dr Bueno focused on biochemical and neurophysiological hallmarks of disorders that are known to affect the central nervous system, such as Down syndrome, Attention Deficit Hyperactivity Disorder, pre-eclampsia and neural disorders induced by obesity.

Dr Bueno investigated in his PhD the effects of dietary fats on adipose tissue metabolism, and how different types of fat can influence disorders such as inflammation and diabetes. In his MPhil Dr Bueno investigated the impact of surgical removal of fat pads on metabolic adaptations in obesity induced by diet and by neurochemical malfunctioning.

Dr Bueno graduated as a Biomedical Scientist – Medical Modality – from Paulista School of Medicine, Sao Paulo Federal University in Brazil. He has extensive experience in clinical sciences, having worked and taught in a leading Tertiary Referral Hospital. His current area of research includes the biochemistry of dietary fats and their role in oxidative stress, brain metabolism and function. More specifically, Dr Bueno researches the many roles of fatty acids and lipids in the development of mild chronic inflammatory states, including liver disease, diabetes, cardiovascular disorders and neuroinflammation. Dr Bueno also researches the interplay between plant polyphenolic compounds and lipids in metabolic diseases and their potential association with neurological states.

 Dr Bueno is a Scientific Advisor of the Food Standards Agency. In June 2023, Dr Bueno was made permanent Chair of the Joint Expert Group on Additives, Enzymes and other regulated products - AEJEG | Committee on Toxicity (food.gov.uk) 

Teaching & Research

Taught modules

BIOS 2106 Systems Physiology I (Cardiovascular and Respiratory Physiology)

BIOS 3108 Systems Physiology II (Neurophysiology)

BIOS 3304 Human Nutrition and Disease Management

BIOS3404 Neuroendocrinology

 

Research

Dr Bueno is a founding member of the Worcester Biomedical Research Group (WBRG) and is currently involved in several research projects:

 

  • The effects of plant polyphenols and essential fatty acid supplementation on cell membrane phospholipid composition in obese rats and in cell models of neural degeneration
  • Associations between high fat diet intake, oestrogen replacement therapies and depressive-like behavioural symptoms in rats
  • Associations between fatty acid intake and biomarkers of cardiovascular health in pre-menopausal women
  • The impact of a group intervention to improve nutritional intake and promote behaviour change for women who have had treatment for breast cancer

PhD Project Ideas

External Collaborators

Prof Eliane Beraldi Ribeiro – Department of Physiology, Sao Paulo Federal University, Brazil

Dr Cristiane de Oliveira – Mayo Clinic, Phoenix, Arizona, USA

Prof Michael Crawford, PhD, FSB, FRCPath – Faculty of Medicine, Imperial College London

Dr Monica Telles – Department of Biological Sciences, Sao Paulo Federal University, Brazil

Dr Rosangela Passos de Jesus – Department of Nutrition Sciences, Bahia Federal University, Brazil

Dr Pedro Gonzalez Muniesa – Department of Nutrition, Food Science and Physiology, University of Navarra, Spain

Dr Joao Felipe Mota – Faculty of Nutrition, Goias Federal University, Brazil

Prof Dan Linetzky Waitzberg – School of Medicine, University of Sao Paulo, Brazil

 

Professional Bodies

Registered Nutritionist, Association for Nutrition

Professional member of the Encephalitis Society 

Full length peer-reviewed publications

      1. Hirata BKS, Aono AH, Machado MMF, Joyce EC, Bueno AA, Kuroshu RM, Oyama LM, Ribeiro EB, Niero CV, Telles MM. Ginkgo biloba extract (GbE) restores gut microbiota dysbiosis in a rat model of lard-rich diet-induced obesity. Phytomedicine Plus. 2023 Jun; 3(3) 100467. https://doi.org/10.1016/j.phyplu.2023.100467.
      2. Santos HO, May TL, Bueno AA. Eating more sardines instead of fish oil supplementation: Beyond omega-3 polyunsaturated fatty acids, a matrix of nutrients with cardiovascular benefits. Front Nutr. 2023 Apr 14;10:1107475. https://doi.org/10.3389/fnut.2023.1107475
      3. de Avelar CR, Nunes BVC, da Silva Sassaki B, Dos Santos Vasconcelos M, de Oliveira LPM, Lyra AC, Bueno AA, de Jesus RP. Efficacy of silymarin in patients with non-alcoholic fatty liver disease - the Siliver trial: a study protocol for a randomized controlled clinical trial. Trials. 2023 Mar 10;24(1):177. doi: 10.1186/s13063-023-07210-6. PMID: 36899430.
      4. Côrtes DM, da Silva Baqueiro Boulhosa RS, Luiz da Silva Lima Paz C, de Magalhães Cunha C, de Oliveira LPM, Lyra AC, Bueno AA, de Jesus RP. Handgrip strength is associated with 12 months survival in male patients suffering with advanced chronic liver disease. J Hum Nutr Diet. 2023 Feb 15. doi: 10.1111/jhn.13160.
      5. De Jesus RP, Boulhosa RSSB, Oliveira LPM, Cunha CM, Matos AN, Bueno AA, Lyra AC. Diet, Gut Dysbiosis and Liver Cirrhosis and their Influence upon Hepatic Encephalopathy. Medical Research Archives 10(8) Aug 2022. ISSN 2375-1924.
      6. Rios TC, Boulhosa RSSB, da Costa MLV, Sassaki B, Bueno AA, De Jesus RP, de Oliveira LPM. Two distinct nutritional assessment tools have dissimilar outcomes in a sample of older adult patients with cancer. Forum of Clinical Oncology. 2022. ISSN eISSN: 1792-362X (In Press)
      7. Watanabe RLH, Boldarine VT, Pedroso AP, Telles MM, Dornellas APS, Wang Y, Bueno AA, Ribeiro EB. Soybean oil prevents hypothalamic N3 fatty acid composition but does not prevent peripheral tissue fatty acid disturbance in rats. Revista Argentina de Endocrinología y Metabolismo (Argentine Journal of Endocrinology and Metabolism), 2022, 59 (2) 24-40. ISSN 0326-4610
      8. Richardson J, Erol R, Bueno AA. A Reflection on the Tensions of Acting in Dual Roles of Doctoral Researcher and Practitioner when Evaluating a Lifestyle Intervention for Breast Cancer Patients. J Cancer Educ. 2022 May 23. doi: 10.1007/s13187-022-02180-w.
      9. Price JC, Santos HO, Bueno AA. The effectiveness of automated digital health solutions at successfully managing obesity and obesity-associated disorders: A PICO-structured investigation. Digital Health. January 2022. doi:10.1177/20552076221091351
      10. Casagrande BP, Bueno AA, Pisani LP, Estadella D. Hepatic glycogen participates in the regulation of hypothalamic pAkt/Akt ratio in high-sugar/high-fat diet-induced obesity. Metab Brain Dis. 2022 Mar 22. doi: 10.1007/s11011-022-00944-3.
      11. de Jesus RP, de Carvalho JF, de Oliveira LPM, Cunha CM, Alves TCHS, Vieira STB, Figueiredo VM, Bueno AA. Metabolic and nutritional triggers associated with increased risk of liver complications in SARS-CoV-2. World J Hepatol. 2022; 14(1): 80-97
      12. Rios TC, de Oliveira LPM, da Costa MLV, da Silva Baqueiro Boulhosa RS, Roriz AKC, Ramos LB, Bueno AA. A poorer nutritional status impacts quality of life in a sample population of elderly cancer patients. Health Qual Life Outcomes. 2021 Mar 17;19(1):90.
      13. Boldarine VT, Joyce E, Pedroso AP, Telles MM, Oyama LM, Bueno AA, Ribeiro EB. Oestrogen replacement fails to fully revert ovariectomy-induced changes in adipose tissue monoglycerides, diglycerides and cholesteryl esters of rats fed a lard-enriched diet. Sci Rep. 2021 Feb 15;11(1):3841.
      14. Genario R, Cipolla-Neto J, Bueno AA, Santos HO. Melatonin supplementation in the management of obesity and obesity-associated disorders: a review of physiological mechanisms and clinical applications. Pharmacol Res. 2020 Oct 17;105254.
      15. Santos HO, Price JC, Bueno AA. Beyond Fish Oil Supplementation: The Effects of Alternative Plant Sources of Omega-3 Polyunsaturated Fatty Acids upon Lipid Indexes and Cardiometabolic Biomarkers-An Overview. Nutrients. 2020 Oct 16;12(10):E3159.
      16. Santos HO, Tinsley GM, da Silva GAR, Bueno AA. Pharmaconutrition in the Clinical Management of COVID-19: A Lack of Evidence-Based Research But Clues to Personalized Prescription. J Pers Med 2020 Sep 25;10(4):E145.
      17. Boldarine VT, Pedroso AP, Brandão-Teles C, LoTurco EG, Nascimento CMO, Oyama LM, Bueno AA, Martins-de-Souza D, Ribeiro EB. Ovariectomy modifies lipid metabolism of retroperitoneal white fat in rats: a proteomic approach. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E427-E437.
      18. Lopes Sakamoto F, Metzker Pereira Ribeiro R, Amador Bueno A, Oliveira Santos H. Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia. Pharmacol Res. 2019 Sep;147:104395.
      19. Genario R, Morello E, Bueno AA, Santos HO. The usefulness of melatonin in the field of obstetrics and gynecology. Pharmacol Res. 2019 Jul 2;147:104337.
      20. Hirata BKS, Cruz MM, de Sá RDCC, Farias TSM, Machado MMF, Bueno AA, Alonso-Vale MIC, Telles MM. Potential Anti-obesogenic Effects of Ginkgo biloba Observed in Epididymal White Adipose Tissue of Obese Rats. Front Endocrinol (Lausanne). 2019 May 10;10:284.
      21. Santos HO, Bueno AA, Mota JF. The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacol Res. 2018 Nov; 137:170-178.
      22. de Jesus RP, Mota JF, González-Muniesa P, Waitzberg DL, Telles MM, Bueno AA. Plant Polyphenols in Obesity and Obesity-Associated Metabolic Disorders: A Narrative Review of Resveratrol and Flavonoids Upon the Molecular Basis of Inflammation. J Obes Nutr Disord 2018; 2JOND-129. DOI: 10.29011/2577-2244. 100029
      23. Wadley AJ, Holliday A, Morgan RG, Heesom KJ, Aldred S, Peters DM, Bueno AA, Coles SJ. Preliminary evidence of reductive stress in human cytotoxic T cells following exercise. J Appl Physiol (1985). 2018 Aug 1;125(2):586-595.
      24. Chao A, Waitzberg D, de Jesus RP, Bueno AA, Kha V, Allen K, Kappus M, Medici V. Malnutrition and Nutritional Support in Alcoholic Liver Disease: a Review. Curr Gastroenterol Rep. 2016 Dec;18(12):65.
      25. Dornellas AP, Watanabe RL, Pimentel GD, Boldarine VT, Nascimento CM, Oyama LM, Ghebremeskel K, Wang Y, Bueno AA, Ribeiro EB. Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions. Prostaglandins Leukot Essent Fatty Acids. 2015 Dec;102-103:21-9.
      26. Bueno AA, Brand A, Neville MM, Lehane C, Brierley N, Crawford MA. Erythrocyte phospholipid molecular species and fatty acids of Down syndrome children compared with non-affected siblings. Br J Nutr. 2014 Nov 24:1-10.
      27. Gomes AC, Bueno AA, de Souza RG, Mota JF. Gut microbiota, probiotics and diabetes. Nutr J. 2014 Jun 17;13:60.
      28. Gow RV, Vallee-Tourangeau F, Crawford MA, Taylor E, Ghebremeskel K, Bueno AA, Hibbeln JR, Sumich A, Rubia K. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2013 Jun;88(6):411-8.
      29. Gow RV, Sumich A, Vallee-Tourangeau F, Angus Crawford M, Ghebremeskel K, Bueno AA, Hibbeln JR, Taylor E, Wilson DA, Rubia K. Omega-3 fatty acids are related to abnormal emotion processing in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2013 Jun;88(6):419-29.
      30. Ionescu N, Freitas C, Bueno AA. Perturbations in Blood Phosphatidylcholine and Sphingomyelin Fatty Acid Composition in a Sample Population of Cigarette Smokers. Indian J Clin Biochem. 2013 Oct;28(4):361-7.
      31. Bueno AA, Ghebremeskel K, Bakheit KH, Elbashir MI, Adam I. Dimethyl acetals, an indirect marker of the endogenous antioxidant plasmalogen level, are reduced in blood lipids of Sudanese pre-eclamptic subjects whose background diet is high in carbohydrate. J Obstet Gynaecol. 2012 Apr;32(3):241-6.
      32. Estadella D, Oyama LM, Bueno AA, Habitante CA, Souza GI, Ribeiro EB, Motoyama CS, Oller do Nascimento CM. A palatable hyperlipidic diet causes obesity and affects brain glucose metabolism in rats. Lipids Health Dis. 2011 Sep 23;10:168.
      33. Bueno AA, Habitante CA, Oyama LM, Estadella D, Ribeiro EB, Oller do Nascimento CM. White adipose tissue re-growth after partial lipectomy in high fat diet induced obese wistar rats. J Physiol Sci. 2011 Jan;61(1):55-63.
      34. Carvalho CR, Bueno AA, Mattos AM, Biz C, de Oliveira C, Pisani LP, Ribeiro EB, do Nascimento CM, Oyama LM. Fructose alters adiponectin, haptoglobin and angiotensinogen gene expression in 3T3-L1 adipocytes. Nutr Res. 2010 Sep;30(9):644-9.
      35. Habitante CA, Oyama LM, Bueno AA, Ribeiro EB, Estadella D, Dâmaso AR, Nascimento CM. Exercise training in rats impairs the replenishment of white adipose tissue after partial lipectomy. Eur J Appl Physiol. 2010 Jun;109(3):371-7.
      36. Bueno AA, Oyama LM, de Macedo Motoyama CS, da Silva Biz CR, Silveira VL, Ribeiro EB, Oller do Nascimento CM. Long chain saturated fatty acids increase haptoglobin gene expression in C57BL/6J mice adipose tissue and 3T3-L1 cells. Eur J Nutr. 2010 Jun;49(4):235-41.
      37. Pisani LP, Oller do Nascimento CM, Bueno AA, Biz C, Albuquerque KT, Ribeiro EB, Oyama LM. Hydrogenated fat diet intake during pregnancy and lactation modifies the PAI-1 gene expression in white adipose tissue of offspring in adult life. Lipids Health Dis. 2008 Apr 4;7:13.
      38. Pisani LP, Oyama LM, Bueno AA, Biz C, Albuquerque KT, Ribeiro EB, Oller do Nascimento CM. Hydrogenated fat intake during pregnancy and lactation modifies serum lipid profile and adipokine mRNA in 21-day-old rats. Nutrition. 2008 Mar;24(3):255-61.
      39. Bueno AA, Oyama LM, de Oliveira C, Pisani LP, Ribeiro EB, Silveira VL, Oller do Nascimento CM. Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. Pflugers Arch – European Journal of Physiology 2008 Jan;455(4):701-9.
      40. Bueno AA, Oyama LM, Estadella D, Habitante CA, Bernardes BS, Ribeiro EB, Oller Do Nascimento CM. Lipid metabolism of monosodium glutamate obese rats after partial removal of adipose tissue. Physiol Res. 2005;54(1):57-65.
      41. Naghettini AV, Nogueira PC, Juliano M, Bueno AA, Casarini DE, de Abreu Carvalhaes JT. Tubular urinary enzymes in acute post-infectious glomerulonephritis. Pediatr Nephrol. 2001 Sep;16(9):719-22.

       

      Chapters of Books and other relevant publications

      1. Beyond Fish Oil Supplementation: The Effects of Alternative Plant Sources of Omega-3 Polyunsaturated Fatty Acids upon Lipid Indexes and Cardiometabolic Biomarkers—An Overview. In: Diets, Foods and Food Components Effect on Dyslipidemia. MDPI. ISBN 978-3-0365-1238-9 (Hbk); ISBN 978-3-0365-1239-6 (PDF). https://doi.org/10.3390/books978-3-0365-1239-6
      2. Capítulo 165: Flavonóides e Resveratrol na prevenção e tratamento de doenças crônicas não transmissíveis (Flavonoids and resveratrol in the prevention and treatment of non-communicable chronic diseases). In: Nutrição Oral, Enteral e Parenteral na Prática Clínica, 5th Edition. Dan L Waitzberg (Waitzberg D). 3296 pages. Editora Atheneu Publishers, Sao Paulo, Brazil. ISBN: 9788538807933
      3. Funcao endocrina do tecido adiposo (The endocrine function of adipose tissue). In: Obesidade. Ana Damaso (Damaso AR). Medsi Medical Publishers, Sao Paulo, Brazil. ISBN: 8571993521.
      4. O pancreas endocrino (The endocrine pancreas). In: Fisiologia Endocrina. Eliane Beraldi Ribeiro (Ribeiro EB). Editora Manole Publishers, Rio de Janeiro, Brazil. ISBN: 9788520426609
      5. O Papel secretor do tecido adiposo (The endocrine role of the adipose tissue). In: Fisiologia Endocrina. Eliane Beraldi Ribeiro (Ribeiro EB). Editora Manole Publishers, Rio de Janeiro, Brazil. ISBN: 9788520426609
      6. EU nutrition rule will deceive consumers. Letters to the Editor – The Times. Signatory. Published 30 September 2009.
      1. Outcome of the Public consultation on the Draft Opinion on Dietary Reference Values for fats. Scientific Report of EFSA – European Food Safety Authority. Signatory. EFSA Journal 2010; 8(5):1507
      1. Bueno AA, Nascimento CMO. Efeito da lipectomia sobre o metabolismo do tecido adiposo de ratos tornados obesos por dieta de cafeteria. Revista Ciência Hoje. Sociedade Brasileira para o Progresso da Ciência, 2003 Sep; 197(1): 50-51. ISSN: 0101-8515.
      2. De Oliveira C, Bueno AA, Oyama LM, Do Nascimento CO. Effects of fatty acids and glucocorticoids on the adiponectin gene expression. Annals of Nutrition and Metabolism, Karger Allschwilerstrasse Switzerland. 2007; 51:226
      3. Bueno AA, Oyama LM, Ribeiro EB, Nascimento CMO. Efeito da lipectomia sobre o metabolism do tecido adiposo de ratos obesos. Jornal da Paulista. 2004; 176(1): 11-15.

Qualifications

  • 2016 - University of Worcester, PGCert Learning and teaching in Higher Education
  • 2010 - Ashford and St. Peter's Hospitals NHS Trust London, Phlebotomy certification
  • 2007 - Sao Paulo Federal University, PhD in Human Nutrition
  • 2003 - Sao Paulo Federal University, MPhil in Nutritional Physiology
  • 2000 - Sao Paulo Federal University Paulista School of Medicine, BMedSc Biomedical Sciences, Medical Modality