Dr. Mathieu Di Miceli

Mathieu photo

Lecturer in Biomedical Science

School of Science and the Environment

Biological Sciences

Contact Details

email: m.di-miceli@worc.ac.uk

Dr Mathieu Di Miceli is a lecturer in Biomedical Science. Mathieu joined the University of Worcester in 2021 for his expertise in neuroscience. He is an expert in electrophysiology, the study of electrical activities in cells. As a member of the Worcester Biomedical Research Group, he is currently investigating the pathological alterations that can lead to neurophysiological dysfunctions in the brain, using in silico models. These include protein-ligand interactions, neural circuits and large-scale datasets. Mathieu is a Fellow of the Higher Education Academy and his teaching is focused on anatomy, physiology, neuroscience, pharmacology, epidemiology and bioinformatics.


  • BSc in Physiology & Neuroscience, 2010 (University of Montpellier, France)
  • MSc in Endocrinology & Neuroscience, 2012 (University of Montpellier, France)
  • PhD in Neuropharmacology & Electrophysiology, 2016 (De Montfort University, England)
  • MCU69 for teaching Neuroscience, 2019 (University of Bordeaux, France)
  • FHEA, 2024 (University of Worcester, England)

Teaching Interests

  • BIOL1004 Human Anatomy and Physiology – Lecturer & Module Leader
  • BIOL1003 Health and Disease – Lecturer
  • BIOL2002 Systems Physiology I – Lecturer & Module Leader
  • BIOL3003 Systems Physiology II – Lecturer
  • BIOL3004 Pharmacology – Lecturer
  • BIOL3009 Genomics & Bioinformatics – Lecturer & Module Leader
  • BIOS0003 Essential Skills for Scientists – Lecturer

Previous Modules:

  • BIOS2104 Human Genetics – Lecturer & Module Leader
  • BIOS0002 Earth, Life & Diversity – Lecturer

Research Interests

Mathieu started his career in neurophysiology in 2012, In the team of Dr Mireille Natoli-Lerner. The focus was on epileptiform activity in an in vitro model of epilepsy, using patch-clamp field electrophysiology. This research aimed at understanding how dysfunctions the blood brain barrier could lead to epilepsy.

Mathieu pursued his career studying myocardial infraction in acutely dissociated cardiac myocytes from rats, in the team of Dr Alain Lacampagne. This project aimed at understanding if the antioxidant molecule N Acetyl Cystein could improve the excitability and/or the contractibility of cardiomyocytes, using field electrophysiology.

In 2012, Mathieu joined De Montfort University, in Dr Gronier’s team, where his PhD project focused on the possible long-term consequences of psychostimulant intake. More precisely, the study was about the relationship between methylphenidate exposure and neurochemical alterations in brain regions controlling motivation and cognition, using in vivo single-cell extracellular electrophysiology.

Mathieu's post-doctoral studies, in Dr Sophie Layé’s team, focused on the relationship between dietary polyunsaturated fatty acids, endocannabinoid receptors and synaptic plasticity, using ex vivo patch clamp electrophysiology.

Mathieu's research interests include basal ganglia neurophysiology, neuronal circuitry and in silico models. Besides, Mathieu is also fascinated about big data analysis, using bioinformatics.

Mathieu also has keen interests in astrophysics and generative art.

Recent Publications

  • Dimitrakopoulos, G. and Di Miceli, Mathieu (2024) Editorial: Bioinformatics for modern neuroscience. Frontiers in Computational Neuroscience, 18. ISSN 1662-5188
  • Cherry, Amy , Wheeler, Mike, Mathisova, Karolina and Di Miceli, Mathieu (2024) In silico analyses of the involvement of GPR55, CB1R and TRPV1: response to THC, contribution to temporal lobe epilepsy, structural modeling and updated evolution. Frontiers in Neuroinformatics, 18. pp. 1-20. ISSN 1662-5196
  • Di Miceli, Mathieu (2023) Diversity in the United Kingdom: Quantification for higher education in comparison to the general population. European Journal of Education. ISSN 0141-8211
  • Martin, H., Coursan, A., Lallement, J., Di Miceli, Mathieu , Kandiah, J., Raho, I., Buttler, J., Guilloux, J-P., De Deurwaerdere, P., Layé, S., Routh, V.H., Guiard, B., Magnan, C., Cruciani-Guglielmacci, C. and Fioramonti, X. (2023) Serotonergic neurons are involved in the counter-regulatory response to hypoglycemia. Journal of Neuroendocrinology. ISSN Print: 0953-8194 Electronic: 1365-2826
  • Marie, A., Kinet, R., Helbling, J-C., Darricau, M., Alfos, S., Di Miceli, Mathieu , Angelo, M-F., Foury, A., Richard, E., Trifilieff, P., Mallet, N.P. and Bosch-Bouju, C. (2023) Impact of dietary vitamin A on striatal function in adult rats. The FASEB Journal, 38 (8). e23037. ISSN Print: 0892-6638 Online: 1530-6860
  • Martin, H., Bullich, S., Martinat, M., Chataigner, M., Di Miceli, Mathieu , Simon, V., Clark, S., Butler, J., Schell, M., Chopra, S., Chaouloff, F., Kleinridders, A., Cota, D., De Deurwaerdere, P., Pénicaud, L., Layé, S., Guiard, B. and Fioramonti, X. (2022) Insulin modulates emotional behavior through a serotonin-dependent mechanism. Molecular Psychiatry. ISSN Print: 1359-4184 Online: 1476-5578
  • Di Miceli, Mathieu , Derf, A. and Gronier, B. (2022) Consequences of Acute or Chronic Methylphenidate Exposure Using Ex Vivo Neurochemistry and In Vivo Electrophysiology in the Prefrontal Cortex and Striatum of Rats. International Journal of Molecular Sciences, 23 (15). p. 8588. ISSN 1422-0067
  • Di Miceli, Mathieu , Martinat, M., Rossitto, M., Aubert, A., Alashmali, S., Bosch-Bouju, C., Fioramonti, X., Joffre, C., Bazinet, R. P. and Layé, S. (2022) Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice. International Journal of Molecular Sciences, 23 (12). ISSN 1422-0067
  • Chataigner, M., Lucas, C., Di Miceli, Mathieu , Pallet, V., Laye, S., Mahaignerie, A., Bouvret, E., Dinnel, A.L. and Joffre, C. (2021) Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging. Frontiers in Nutrition, 8 (75029). ISSN 2296-861X
  • Di Miceli, Mathieu , Omoloye, A. and Gronier, B. (2021) Characterisation of methylphenidate-induced excitation in midbrain dopamine neurons, an electrophysiological study in the rat brain. Progress in neuro-psychopharmacology & biological psychiatry, 112. p. 110406. ISSN 0278-5846

Membership of Professional Bodies

  • FHEA

External Roles

  • External Examiner for the University of Ulster
  • Reviewer for several journals